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Kidney disease affects millions of people worldwide and ranges from mild loss of kidney function to chronic kidney disease (CKD), kidney failure, and complex disorders such as glomerulonephritis, polycystic kidney disease, and diabetic nephropathy. Because the kidneys regulate fluid balance, electrolytes, blood pressure, red blood cell production, and waste removal, any decline in kidney function can influence nearly every organ system. Conventional treatment for kidney disease often includes bl...
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The role of CD47 in cell migration was first demonstrated for neutrophils, where CD47 blocking antibodies inhibited transmigration of neutrophils and monocytes through the endothelium. These results were shown to be dependent on avb3 integrins, which interact with and are activated by CD47 at the plasma membrane. Initially found by Irving Weissman’s group at Stanford College, blocking CD47 function has been proven to inhibit migration and metastasis in a variety of tumor models. If you adored t...
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